Stem Cells Could Be The Future of Hair Regrowth

Although hair loss is common, it can have a huge impact on a person’s self-esteem and, subsequently, their physical and mental well-being. 

New trials exploring the potential applications of stem cells in treating hair loss offer hope for those who are suffering both now and in the future. Post by: Stem Cell News, Stem Cell Therapies on Jan 10, 2024. https://cells4life.com/2024/01/stem-cells-could-be-the-future-of-hair-regrowth/

What causes different types of hair loss?

The root causes of hair loss in both men and women are varied. 

Amongst the most common types of hair loss is androgenetic alopecia (otherwise known as pattern baldness in both men and women).

Although the essential causes of this form of hair loss are somewhat unknown, experts understand androgenetic alopecia to arise from the overstimulation of hair follicles by a hormone called androgen.

This in turn leads to a shorter growth cycle and results in hair thinning and loss. [1]

Another fairly common disorder affecting hair follicle growth is alopecia areata. This auto-immune disease causes a breach in the immune-privilege afforded to hair follicles.

Other causes of hair loss include the effects of increased cortisol levels from stress, trauma and grief, along with the side effects of certain medical treatments, like chemotherapy. [2]

 

What options are currently available?

Because of the commonality of hair loss, demand for treatments to regrow, replenish or transplant hair are correspondingly widespread.

At the moment, treatments for hair loss include medications like Finasteride and Minoxidil, strictly topical medications like prostaglandins and cetirizine, along with Low-Level Laser Therapy and Platelet Rich Plasma Therapy.

There is also a wide array of natural ingredients thought to help prevent hair loss, like niacin, sage, and green tea.

In recent years there have also been significant advances in research into the possible uses of stem cells in treating hair loss. 

The application of stem cells from the hair follicle, adipose tissue and from umbilical cord blood for hair replenishment or even regrowth are all currently being investigated in over a thousand clinical trials.

Using stem cells from hair follicles

The mesenchymal stem cells that differentiate into hair follicles require chemical activation to begin the process of differentiation.

When this chemical activation doesn’t happen, follicular degeneration begins, and hair growth stops.

Researchers at the University of California, Los Angeles have identified two drugs that can cause this activation in mesenchymal stem cells harvested from hair follicles. [5]

By using one drug, called RCGD423, researchers were able to activate a signalling pathway that increased production of lactate, driving the activation of the follicle stem cells and resulting in increased hair growth.

The other drug, UK5099, was shown to also increase the production of lactate by preventing pyruvate from entering the mitochondria of the hair follicle stem cells, increasing hair growth in mice.

There have also been attempts to inject hair follicle stem cells directly into the scalp.

Researchers in Italy and Albania took biopsies of the ‘bulge’ of the hair follicle (a niche at the bottom of the follicle containing stem cells) which were then trimmed and centrifuged to separate the cells.

These cells were then injected into a site on the scalp and the results were monitored over 23 weeks. 

Researchers found significant improvements in hair density and hair count compared to placebo areas, suggesting that this method for treating hair loss may have huge potential for other hair loss sufferers.

In conclusion, while hair loss is a common issue with diverse underlying causes, its impact on self-esteem and overall well-being cannot be understated. Current treatments, ranging from medications to therapies like PRP and laser treatments, provide options for those seeking to manage or reverse hair loss. However, the emerging field of stem cell therapy represents an exciting frontier in hair restoration.

At American Mane, we specialize in advanced mesotherapy treatments, which utilize growth factors and bioactive molecules derived from stem cells. These innovative therapies are designed to stimulate hair follicle regeneration, improve scalp health, and promote natural hair growth. Our personalized approach ensures that every patient receives a treatment tailored to their unique needs and goals, offering a highly effective solution for combatting hair loss.

With ongoing research and advancements in stem cell applications—such as chemical activation of follicle stem cells and direct stem cell injections—patients can look forward to transformative solutions. Combined with the cutting-edge treatments available at American Mane, the future of hair regrowth holds immense promise for individuals grappling with hair loss.